Conversion of D-phenylalanine to L-phenylalanine in humans.
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چکیده
منابع مشابه
Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria
Self-assembly of phenylalanine is linked to amyloid formation toxicity in phenylketonuria disease. We are demonstrating that L-phenylalanine self-assembles to amyloid fibrils at varying experimental conditions and transforms to a gel state at saturated concentration. Biophysical methods including nuclear magnetic resonance, resistance by alpha-phenylglycine to fibril formation and preference of...
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The enzymatic oxidation of phenylalanine to tyrosine has been studied as part of an investigation of the intermediates and enzyme systems involved in the biosynthesis of epinephrine. Womack and Rose (1) indicated that phenylalanine was converted to tyrosine in viva by showing that tyrosine is not essential when sufficient phenylalanine is available. Definite proof was provided by Moss and Schoe...
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To establish an advantageous method for the production of l-amino acids, microbial isomerization of d- and dl-amino acids to l-amino acids was studied. Screening experiments on a number of microorganisms showed that cell suspensions of Pseudomonas fluorescens and P. miyamizu were capable of isomerizing d- and dl-phenylalanines to l-phenylalanine. Various conditions suitable for isomerization by...
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The synthesis of substituted d-phenylalanines in high yield and excellent optical purity, starting from inexpensive cinnamic acids, has been achieved with a novel one-pot approach by coupling phenylalanine ammonia lyase (PAL) amination with a chemoenzymatic deracemization (based on stereoselective oxidation and nonselective reduction). A simple high-throughput solid-phase screening method has a...
متن کاملThe utilization of L- and D-phenylalanine by the rat.
An investigation of the oxidation of phenylalanine has been undertaken in this laboratory in connection with studies of the hereditary defect phenylketonuria (phenylpyruvic oligophrenia), in which the oxidation does not occur in the normal manner. The biochemical defect is accompanied by a profound impairment of mental functioning (2, 3). A knowledge of the details of the oxidation might lead t...
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ژورنال
عنوان ژورنال: Nippon Eiyo Shokuryo Gakkaishi
سال: 1988
ISSN: 1883-2849,0287-3516
DOI: 10.4327/jsnfs.41.7